B Pharm 8th Sem CADD Imp Questions 2024

In this post b pharm 8th sem computer aided drug design important questions are given for 2024. 

By writing answers to all these questions, you can score good marks on the exam and prepare notes on CADD topics. 

Notes prepared in this way prove to help do revision before the examination in less time. 

All the questions given here are mandatory for you. 

Therefore, be careful while writing the answers to these b pharmacy 8th semester cadd model important questions and write informative answers. 

You should try to answer all these questions in your own words. 

You can remember the answers written in your own words easily and conveniently. 

Before writing their answers, your concept on this topic should be clear. 

For this, read the lesson on the topic related to computer aided drug design question paper b pharm 8th sem given here in your university textbook 2 to 3 times and understand the meaning. 

After that try to write the answer. In case of any problem, take the help of your university professor or advanced pharma book. 

In the collection of questions of the question set given below, the help of question bank along with b pharm 8th sem previous year question papers of this topic has been taken. 

An attempt has been made here to include those questions in this set of computer drug design important questions 8th semester, which have been asked many times and continuously in the earlier question papers on this topic. 

There is a strong possibility of those questions being asked again in the upcoming examination. 

You should also know that when you get cadd question paper b pharmacy 8th semester in the examination hall, what are the first steps you must take. 

First of all, you have to check the entire question paper and confirm whether you have received the error-free question paper or not. 

There should not be any question misprinted or page missing in the question paper. 

If it is not so then another fresh question paper should be requested from the invigilator. 

Start writing the answer only after reading the instructions on the first page of the question paper and try to write an informative answer in as many words as you have been asked to write. 

Here, write the long answer of the set given below in 500 words and the short answer in 200 words. 

More such computer aided drug design b pharm questions for practice are available online i.e. on the internet. 

You can download them, use them, and practice as much as possible. 

Let's solve these CADD computer important questions.

Computer Aided Drug Design Questions

B Pharmacy 8th Semester CADD Important Questions

• Explain the methodology of 3D QSAR.
• Define Bioisosterism. 
• Discuss Lead optimization with their characters. Explain the methods of optimization.
• Explain Bioisosteric replacement with any two case studies.
• Explain Random and Non-random screening methods.
• Define Databases and List out their types.
• What is bioinformatics? Write its applications.
• Explain in detail about molecular mechanics.
• Write the advantages and disadvantages of the Semiempirical method.
• Explain Free Wilson's analysis.
• Enlist the different phases of Case studies. 
• Write short notes on the History and development of QSAR.
• Explain the Biosteric replacement strategies with ring replacement.
• Explain Quantum mechanics. Explain the principle of quantum mechanics and its methods.
• Write the formula used to calculate the number of conformations.
• Write short notes on Chemoinformatics and the role of Chemoinformatics in modern drug discovery.
• Write a short note on the following:- (a) Molecular modeling method with flow chart (b) Manual docking (c) Verloop Steric Parameter.
• Explain Molecular Docking.
• Enumerate the properties determined by the researchers for preclinical studies.
• Write a short note on Global conformation minima determination.
• Explain about the ADME Databases.
• Explain Pharmacophore-based screening.
• Write a short note on the following:- (a) Invitro, Invivo, and Silico assays (b) Structure of Isoniazid and Chloramphenicol. 
• Explain serendipitous drug discovery.
• Write a brief note on Non-clinical activities.
• Explain De novo drug design. Explain the steps involved in De novo Drug Design.
• Explain the Rational approaches to Lead Discovery.
• Define Lead.
• Write a short answer on the following:- (a) SNPs- single nucleotide polymorphism (b) LUDI program (c) Advantages and disadvantages of QSAR.
• Define the Partition coefficient.
• Explain Analog-Based Drug Design.
• Define Lipinski’s Rule of Five.
• Write a short note on the following:- (a) Hammett Substituent Constant (b) Biochemical databases (c) Monte-Carlo method in conformational searching (d) Molecular refractivity.
• Explain Hansch's Analysis and Hansch’s equation.
• Write short notes on the following:- (a) Energy Minimization (b) Expand COMFA and COMSIA (c) Expand SAR and QSAR.
• Write the name of the two drugs discovered without Lead.
• Define drug-likeness and the methods for its assessment. 
• Write short notes on the following:- (a) Tafts steric constant (b) Expand LUMO and HOMO.
• Define Pharmacophore. Write the concept of Pharmacophore mapping.
• Write the advantages of Computer-aided drug designing. 
• Define Drug.
• Explain Captopril.
• Explain Rigid Docking.
• Explain Ligand-based (LBVS) and Structure-based (SBVS) techniques in detail.
• Explain Conformational Analysis.
• Write the examples of Amide group Bioisosteres.
• Define flexible docking.

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